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Glutamate-Induced Biophotonic Activities Show Spectral Blueshift in Aging Mice

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【作者】 CHEN Lin-huaWANG ZhuoXIA Cheng-mingXIAO Fang-yanDAI Jia-pei

【Author】 CHEN Lin-hua;WANG Zhuo;XIA Cheng-ming;XIAO Fang-yan;DAI Jia-pei;Wuhan Institute for Neuroscience and Neuroengineering (WINN),South-Central University for Nationalities;Department of Neurobiology,College of Life Sciences,South-Central University for Nationalities;

【通讯作者】 DAI Jia-pei;

【机构】 Wuhan Institute for Neuroscience and Neuroengineering (WINN),South-Central University for NationalitiesDepartment of Neurobiology,College of Life Sciences,South-Central University for Nationalities

【摘要】 Objective:Aging is one of the most important risk factors for Alzheimer’s disease. Previous studies found that neural signal communications and information processing in neural circuits possibly play an important role in neural information communication. Recent study found that glutamate-induced biophotonic activities and transmission in the nervous system present a spectral redshift from animals(in order of bullfrog,mouse,chicken,pig and monkey) to humans,which is consistent with the species evolution tree. This property may be a key biophysical basis for explaining high intelligence in humans because biophoton spectral redshift could be a more effective and economical measure of biophotonic signal communications and information processing in the human brain,However,it is still unclear whether the mechanism may relate to process of aging. Methods:Combining the ultra-weak biophoton imaging system(UBIS) with the improved biophoton spectral analysis device(BSAD),we detected and analyzed the spectral features of glutamate-induced biophotonic emission in brain slices in different age mice. Results:We found that glutamate-induced biophotonic activities and transmission in the brain present a spectral blueshift from young to old mice. This finding suggests that with the increase of age,especially in the process of aging,brain cells need higher energy biophotons to transmit neural information due to the gradual decrease of metabolic activities and the efficiency of nervous system in the process of neural signal transmission and processing. Conclusion:If biophotonic activity is involved in the transmission and coding of neural signals,then the biophoton spectral blueshift could prompt the decrease of signal transmission and processing efficiency with the process of aging,which may possibly be associated with a decline in cognitive ability during aging. This finding may provide new ideas for the prevention and treatment of aging-related diseases such as Alzheimer’s disease.

【Abstract】 Objective:Aging is one of the most important risk factors for Alzheimer’s disease. Previous studies found that neural signal communications and information processing in neural circuits possibly play an important role in neural information communication. Recent study found that glutamate-induced biophotonic activities and transmission in the nervous system present a spectral redshift from animals(in order of bullfrog,mouse,chicken,pig and monkey) to humans,which is consistent with the species evolution tree. This property may be a key biophysical basis for explaining high intelligence in humans because biophoton spectral redshift could be a more effective and economical measure of biophotonic signal communications and information processing in the human brain,However,it is still unclear whether the mechanism may relate to process of aging. Methods:Combining the ultra-weak biophoton imaging system(UBIS) with the improved biophoton spectral analysis device(BSAD),we detected and analyzed the spectral features of glutamate-induced biophotonic emission in brain slices in different age mice. Results:We found that glutamate-induced biophotonic activities and transmission in the brain present a spectral blueshift from young to old mice. This finding suggests that with the increase of age,especially in the process of aging,brain cells need higher energy biophotons to transmit neural information due to the gradual decrease of metabolic activities and the efficiency of nervous system in the process of neural signal transmission and processing. Conclusion:If biophotonic activity is involved in the transmission and coding of neural signals,then the biophoton spectral blueshift could prompt the decrease of signal transmission and processing efficiency with the process of aging,which may possibly be associated with a decline in cognitive ability during aging. This finding may provide new ideas for the prevention and treatment of aging-related diseases such as Alzheimer’s disease.

  • 【文献出处】 神经药理学报 ,Acta Neuropharmacologica , 编辑部邮箱 ,2019年Z1期
  • 【分类号】R749.16
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